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Grant Bio CRF-1 Controlled Rate Freezer

Liquid nitrogen free and cryogen free controlled rate freezer for research into the cryopreservation of a wide range of material including: embryos, stem cells, mammalian cells, spermatozoa, antibodies, tissue sections and rodent organs. The CRF-1 brings accuracy, precision and reproducibility to biological cryopreservation.

Unlike conventional liquid nitrogen based controlled rate cooling equipment, the CRF-1 greatly reduces the risk of contamination and can be used in cleanrooms and barrier facilities. The CRF-1 fits neatly on a bench-top. Its performance in terms of cell viability after freezing is comparable or better than standard liquid nitrogen freezers. As alcohol is not used, there is also a greatly reduced fire risk. The CRF-1 will cool down to -100��C with straws.

The cooling rate of the CRF-1 is precisely controlled, ensuring accuracy and reproducibility throughout the freezing profile, especially for the important nucleation/seeding phase. This ensures optimal recovery of cells upon thawing.

Operation is simple and can be carried out with or without a PC; data can be logged via PC software and cooling profiles are directly displayed on PC screen. Different cooling profiles are available from a drop down menu and customised profiles can be written.

Key Features

  Accurate and reproducible control of cooling rates and sample temperatures
  Easy to use and samples can be nucleated/seeded in-situ
  Linear and non-linear cooling profiles
  Low running costs: estimated at 1% of liquid nitrogen controlled rate freezing
  Temperature remains at -100��C at the end of cycle for straw applications until freezer is switched off
  Uninterruptible Power Supply (UPS): complete cycle run if power fails (supplied as an optional accessory)
  CE marked (laboratory use)
  Servicing and calibration available
  3 year warranty

Data Sheet


The CRF-1 is highly versatile and can be used for the cryopreservation research of a wide range of samples in cryovials, straws, bags, microplates and Matrix-96-well block plates in the following areas:

  Transgenic embryos research
  Stem cell research
  Clinical and research samples, e.g. lymphocytes and tissue cell lines in conventional cryovials
  Various mammalian cells including cardiomyocytes, adipose, liver and muscle
  Cord blood derived stem cells
  Adherent cells and stem cells in microplates
  Cell suspensions in numbered/barcoded arrays
  Robotic integration - the CRF-1 has also successfully been integrated into robotic systems
  Is also suitable for applications in veterinarian IVF

Ordering Information

Controlled rate freezer for 16x0.5ml CBS straws CRF-1 H00

Controlled rate freezer for 18x0.3ml IMV straws CRF-1 H01

Controlled rate freezer for 55x1.8ml cryovials CRF-1 H02

Controlled rate freezer with flat plate CRF-1 H03

Controlled rate freezer plate for 1xSBS microplate CRF-1 H05

Controlled rate freezer for 55x1.8ml deep cryovials CRF-1 H06

Controlled rate freezer with combi plate CRF-1 H07

Controlled rate freezer with combi plate CRF-1 H08

Calibration certificate CAL CRF-1

Maintenance 1 yr. Clean and retest. Test report supplied. Excludes repair and replacement of parts CRF-1 MAINT 1

Cryopen nucleating tool CRF-1 CRYOPEN

Replacement cartridge for cryopen CRF-1 CARTRIDGE

Uninterruptible power system (UPS) for the freezer for a 3 hour cycle in the event of an electrical power failure. CRF-1 UPS

Please note - Product designs and specifications are subject to change without notice. The user is responsible for determining the suitability of this product.

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